Cognition Pharmaceuticals Reports its Lead Compound Statistically Significantly Improves Memory in Ills

Cognition Pharmaceuticals LLC of New York has reported very compelling results of a Phase II trial that demonstrated statistically significant results in a population of patients with cognitive decline associated with Multiple Sclerosis. The results are interesting on many levels. The trial failed to meet its primary end-points that were supposed to measure a drug effect on executive function but its secondary end-points that measured the drug’s effect on memory were significant. It seems Cognition may have had a case of asking the wrong question, but getting a better answer than they either hope for or expected. Cognition, it is time to change the hypothesis.

I tend to cast a jaundiced eye to trials with mixed results; however, the provenance of this agent is extraordinary. Its developers include Mark Bear, the Picower Professor of Neuroscience at MIT (the blog covered his pioneering work in identifying a path to curing Fragile X), Nobel Laureate, Leon Cooper and Neurosurgeon, Mel Epstein. This team represents the smartest kids in the class. The original theory of the compound’s mechanism of action was it would improve memory consolidation. This trial clearly illustrates that type of activity. The trial also confirms results from the compound's results animal models. The former CEO of the Sention, the company that originally developed the compound, commented in a recent book Can't Remember What I Forgot: The Good News from the Front Lines of Memory Research by Sue Halpern, that it, “…shot for the moon and missed.” In fact, Sention was probably on the mark and the compound was simply abandoned before broadly targeted trials were executed (Ms. Halpern, it is time to update your book before its next printing).

Central Nervous System (CNS) drug development is the Vietnam of the pharmaceutical industry. In the last year we have seen compounds from Myriad Genetics, Lexicon, Targacept (multiple indications), Memory Pharmaceuticals (multiple compounds and multiple indications), Nurochem, and Elan, all failed to meet primary end-points and almost all these compounds showed no signal in ills. Thankfully the C105 trial seems to have been well designed and executed. In a rare circumstance, a drug company maintained a mindset driven by science instead of marketing. This trial clearly demonstrates C105 is an active compound. Furthermore, the compound mechanism of action would argue a wide use across a wide variety of indications including but not limited to chemobrain, mild-Cognitive Impairment, cognitive impairment associated with Parkinson’s disease, cognitive impairment associated with Multiple Sclerosis, traumatic brain injury, and Cognition believes childhood learning disabilities.

Given that C105 is a member of the widely used amphetamine family, the development risk for this compound should be limited. Given its safety profile is good, it could be broadly prescribed. Given the dearth of compounds available to treat cognitive conditions, neurologists and psychiatrists are largely confined to offering off-label scripts that have little if any effect on memory improvement such as modafinil (fatigue), anti-depressants and ADHD drugs (attention); this agent demands to be put into multiple trials across a range of illnesses as the patient community not only will desire it but they deserve it. This drug may address a range of underserved illnesses for patients with unmet needs. Time is of the essence.

I will follow-up on this trial once more information is available.

Happy Holidays from The Healing Project

Everyone at the The Healing Project wishes that everyone in our community have the happiest and healthiest of Holidays.

Donations may be made online by following this link to make a donation.

If you don’t care to make an online donation, please feel free to send a donation by mail to:

The Healing Project Inc. (THP)
5 Laurel RdSouth Salem, NY 10590
http://www.thehealingproject.org/
EIN: 20-4345105
E-mail: - info@thehealingproject.org

THP is 501 (c) 3 not-for-profit organization; all donations are tax-deductible.

If your employer has a giving program, please be kind enough to apply for a matching donation.

Finally, if your company wishes to donate, please have its giving officer contact Melissa Marr, melissa@thehealingproject.org to discuss sponsorship.

Thank you so much for your generous support

May you also have a healthy, happy and prosperous New Year.

Change Is Coming to the Veterans Administration

President-elect Obama has announced his new Secretary of Veterans Affairs and it is Gen. Eric Shinseki. He was severely wounded in Vietnam and spent 11 months in the hospital General Shinseki was the US Army Chief of Staff and was forced to retire by Donald Rumsfeld because he was not acting like part of the team. He dissented vigorously regarding the prosecution of the invasion of Iraq. His resolve cost him his job, and he has since been proven right.

His resolve will be tested again as the Bush Administration filled the VA with hacks, incompetents and apologists. James Nicholson followed the Bush party line right off a cliff. Then, General James Peake became Secretary. General Peake when in uniform, as the US Army Surgeon General, failed to acknowledge, prepare and deal with either Traumatic Brain Injury and mental health issues. As a civilian, he continued the policy as it might expose his incompetence. Hopefully, he will quickly retire from the practice of medicine, his tenure has been a disgrace.

General Shinseki should first resolve to clean-up the VAs administrative mess that fails to screen, admit and treat our wounded warriors. The VA would make Soviet apparatchiks blush with its indifference and ineffeciency. Second, he should immediately demote and fire the entire senior management of VA in mental health and traumatic brain injury. The signature injuries of OIF/OEF can be acknowledged and treated. The very capable staffs of many VA sites can be supplemented with civilian resources to get these service members squared away. The policy of denying benefits based on phony science and mindless research by both the DoD and VA can quickly come to an end. Finally, he must seek to chart an independent path; the DoD has an agenda quite seperate from treating and honoring our warriors.

Hopefully this action will signal to Military Health Systems that it is time to clean its house.

MILITARY PERSONNEL WITH TRAUMATIC BRAIN INJURY AT RISK FOR SERIOUS LONG-TERM

The Institute of Medicine reported this week Military personnel who suffer severe or moderate traumatic brain injury (TBI) face an increased risk for developing several long-term health problems. This evidenced based study reported that conditions include Alzheimer's-like dementia, aggression, memory loss, depression, and symptoms similar to those of Parkinson's disease. Even mild TBI is associated with some of these adverse consequences, noted the committee that wrote the report.

In addition, the report notes that brain injuries sustained as a result of exposure to the force of an explosion without a direct strike to the head -- one of the most common perils for soldiers in Iraq and Afghanistan -- may be underdiagnosed due to the lack of research on blast injury. It calls for the U.S. Department of Defense and the U.S. Department of Veterans Affairs to step up clinical and animal studies of blast-induced neurotrauma (BINT).

The Healing Project would go further and immediately screen and database the 300,000 to 400,000 service members exposed to blasts.

"Explosive devices and other weaponry have become more powerful and devastating throughout the wars in Iraq and Afghanistan, and we are seeing much higher rates of nonpenetrating traumatic brain injury and blast-induced injury among military personnel who have served in these countries than in earlier wars," said George W. Rutherford, professor of epidemiology and preventive medicine and vice chair, department of epidemiology and biostatistics, School of Medicine, University of California, San Francisco, and chair of the committee that wrote the report. "It is important to identify and understand any long-term health effects of these injuries so that wounded service members do not lose valuable time for therapy and rehabilitation."

Studies conducted in Iraq by the Air Force Medical Service with the Headminder system would argue that up to 5% of exposures, that is 15,000 to 20,000 m-TBI injuries, would require additional follow-up. The DoD is only reporting 5,500 injuries total traumatic brain injuries. Furthermore, while animal studies are useful, replicating injuries in animals models are unlikely to provide necessary data to provide human clinical guidance. It is time to implement a web-centric longitudinal screening technology to track the evolution of these injuries in an epidemiologically sound fashion.

While we agree with the Institute in broad strokes, scientists and clinicians have been aware of the injuries and the likely outcome of these injuries since 2004. Neither the DoD or the VA has demonstrated any real interest in identifying or treating M-TBI dealing with its attendant co-morbidities. Both organizations have used research to delay the identification of and/or deny the very existence of the injuries. The report makes it clear blast concussion is not like a sports injury nor is it PTSD (two of the DoDs and VAs favorite excuses why they do nothing). Now that we have a change of government, it is time for Secretary of Defense Gates to clean out DoD HA and US Army Medcom. The delayers, the deniers and the dinosaurs need to be quickly cashiered and replaced by people who will get the job done now.

December 1st through the 7th is National Aplastic Anemia and MDS Awareness Week

Aplastic anemia (a-PLAS-tik uh-NEE-me-uh) is a rare and serious blood disorder in which bone marrow stops making enough new blood cells. Bone marrow––the spongy material inside bones—makes new blood cells called stem cells. Stem cells normally develop into three main types of blood cells: red blood cells, white blood cells, and platelets. Each type of blood cell has its own functions in the body.

Aplastic anemia is a rare condition. In the United States, about 500–1,000 people develop this type of anemia each year. It is two to three times more common in Asian countries.

The two main types of aplastic anemia are acquired and hereditary. Acquired means a person develops the condition during his or her lifetime. Hereditary means a person is born with the condition. Acquired aplastic anemia is the most common type, and it is sometimes a temporary condition. It can be triggered by exposure to:

• Toxic chemicals
• Chemotherapy drugs
• Radiation
• Virus infections

However, the cause of acquired aplastic anemia is often not known.

Hereditary aplastic anemia is rare. It occurs with some inherited conditions, such as Fanconi anemia.

Aplastic Anemia & MDS International Foundation, Inc.
P.O. Box 310
Churchton, MD 20733-0310
(800) 747-2820
(410) 867-0242
(410) 867-0240 Fax
mail%20to:help@aamds.org
www.aamds.org
Materials available
Contact: John Huber

December 1st is World AIDS Day

Joint United Nations Programme on HIV/AIDS

Quick Facts on AIDS in the United States

UNAIDS Secretariat:
20, Avenue Appia
CH-1211 Geneva 27
Switzerland
Telephone: +41.22.791.3666
Fax: +41.22.791.4187
mail%20to:unaids@unaids.org
http://www.unaids.org/en/default.asp
Materials available
Contact: None designated

Happy Thanksgiving From The Healing Project

The Healing Project wishes that everyone in our US community has wonderful holiday.

Given this is a celebration on America's bounty, please take a moment to reflect on those that are less fortunate and make a donation to extend our reach to those that have unmet medical needs.

Again have a happy, healthy and enjoyable holiday.

November 20th is Great American Smokeout

It is time to pack it in. The Healing Project knows it isn't easy to go cold turkey but newer drugs like Chantix have demonstrated amazing results in smokers with manageable side-effects. Check for Great American Smokeout programs in your local communites and give it a shot.

Great American Smokeout
American Cancer Society
250 Williams Street NW
Atlanta, GA 30303
(800) ACS-2345 (227-2345)
http://www.cancer.org/

Materials available
Contact: National Office

November is Pulmonary Hypertension Awareness Month

What is PH?
Pulmonary hypertension is a rare blood vessel disorder of the lung in which the pressure in the pulmonary artery (the blood vessel that leads from the heart to the lungs) rises above normal levels and may become life threatening.

Pulmonary Hypertension Awareness Month
Pulmonary Hypertension Association
801 Roeder Road, Suite 400
Silver Spring, MD 20910
(800) 748-7274 Helpline
(301) 565-3004 x109
(301) 565-3994 Fax
pha@phassociation.org

http://www.phassociation.org/

Materials available
Contact: Katie Kroner

November is National Hospice Palliative Care Month

The Healing Project strongly advocates the pateints and caregivers consider hospice care as the end-of-life approaches. These facilities offer a kind and compassionate place to come to terms with one's mortality.

1.3 million people with life-limiting illness received care from the nation’s 4,500 hospice providers last year. This represents continued growth in both patients served and number of providers. Approximately 35 percent of all deaths in the US were under the care of a hospice program.

Additionally, the top five diagnoses among hospice patients reported by NHPCO show the continued trend of less cancer patients among those served. The top five diagnoses seen in hospice for 2006 are as follows:

Cancer 44.1 percent
Heart Disease 12.2 percent
Debility 11.8 percent
Dementia 10.0 percent
Lung Disease 7.7 percent

Throughout the month of November, hospice and palliative care organizations across the nation are hosting activities to educate the public and other healthcare professionals about the benefits of hospice and palliative care.

Hospice is not a place but a philosophy of care created to help people live with dignity, comfort, and compassion at the end of life. Palliative care works to bring this philosophy of care to people earlier in the course of a serious illness.

Hospice and palliative care programs provide pain management, symptom control, psychosocial support, and spiritual care to patients and their families. They also serve as valuable community resources about care options.

Additional information about hospice, palliative care, advance care planning, and talking with loved ones about these important issues is available from NHPCO’s Caring Connections. For information, to find a local hospice, or to get a free state-specific advance directive form, visit
http://www.caringinfo.org/ or call the HelpLine at 800/658-8898.

National Hospice Palliative Care Month
National Hospice and Palliative Care Organization
1700 Diagonal Road, Suite 625
Alexandria, VA 22314
(703) 837-1500 or (703) 837-3139
(703) 837-1233 Fax
jradulovic@nhpco.org
http://www.nhpco.org/
Contact: Jon Radulovic

The New President and Healthcare - Part II - Medical Services

Before wholesale changes are made to US healthcare system, Mr. Obama should fix the two health systems that federal government controls. The Military Health System and the Veterans Administration are two of the largest health systems in the United States and have serious problems.

The critical problems with these entities are led by incompetent, indifferent and anti-scientific management. Mr. Obama should immediately request the Bush Administration remove S. Ward Casscells, M.D. and Ellen Embrey. These two individuals are directly responsible for the lack of progress in the treatment of mental illness, mild-traumatic brain injury, traumatic brain injury, suicide and PTSD. They have led a campaign to continue the Bush Administration policy to underreport casualties in the Iraq and Afghanistan conflicts. Further, these individuals have aided and abetted the US Army’s program to deny benefits to wounded and disabled service members. Finally, they will babble endlessly about what we don’t understand about these injuries so it will require years of research. In fact, much more is known about these injuries then they would like Congress to believe. However, these scientific facts fly in the face of their political objectives so they have let contracts to friends of the US Army who will confuse the issue for years.

What to do following the dismissal of Dr. Casscells and Ellen Embrey.

First, quickly review all contracts let by these individuals for contract irregularities and pursue criminal prosecution. Next, remove the US Army from all leadership positions in programs related to mental health and brain injury. The US Army personnel should be replaced by officers from the Air Force and the Navy. The Air Force and Navy are more technologically enabled and lack a political agenda as both branches have honored their disability payments. It is not to say the US Army lacks officers with technical expertise in the areas of mental health or traumatic brain injury but they were excluded from the process because they could not get with the program. Instead, the US Army replaced them with people qualified as occupational therapists and physicians’ assistants. It is time to get organized and led by the right talent. Mental health and traumatic brain injury issues can be solved and could have been largely avoided if it had not become political. Finally, embrace the civilian medical sector. Much of the most advanced research in mental health and traumatic brain injury is at specialized centers such as the Kessler Institute in New Jersey. Civilian entities were willing an able to take a leading role in solving these problems but were denied participation by the hacks running MHS and the VA.

With regard to the VA, Mr. Obama should immediately remove the entire senior management. Dr. Jim Peake is the former US Army Surgeon General. When in uniform, he was part of the program that left the nation unprepared to deal with mental health and traumatic brain injury issues. He not only failed for active service members but also rewarded with even greater responsibility so he could fail them once of service members became veterans. Since the VA is evolved into a system to treat geriatric patients, the surge in younger service members should be guided to civilian medical resources at government expense. The major exception is in PTSD where the VA and CDC did some of the most distinguished work both scientifically and clinically. The VA needs to get some younger more aggressive leadership in this area and capitalize on the VAs expertise. It should also embrace private psychologists to screen and treat the less serious cases locally and triage the most complex cases to VA centers of excellence.

Again, the medical failure at MHS and the VA is not as much a monetary problem as it is a management problem. Last year $2,1B was distributed by Congress to the VA and MHS to treat wounded with TBI and mental health issues. Nonetheless, the leadership is unable to account for much of the spending and the results have been almost nonexistent. With little doubt, the bulk of our service members could have been identified and started treatment. It does and will require funds but funds well spent. Let’s fix the problem and stop the talk.

The New President and Healthcare - Part I - Research

Now that the United States has elected a new president, it is time for Mr. Obama that his talk of change is more than just talk. Mr. Obama has also implied that the US Federal Government can have a powerful and positive impact on healthcare.

The Federal Government is already a major force in healthcare ranging from basic research to direct provision of medical services to reimbursement of fee for service medical services. While enormous amounts of money are thrown into US healthcare, the results are have been less than stellar for the past 30 years. It is time to clean this mess up, and he should start will what the Federal government directly controls.

US Government research has been corrupted by politics for decades. The NIH, CDC and DoD value filling out forms more than the quality of the minds engaged in research. The peer review panels guide funding to politically connected individuals and entities or influenced by professional conflicts. The research is often conducted in the districts of well-connected congressman at third and fourth tier universities by third and fourth tier researchers. Much of the research is funded without results. Failure is fine and expected but what is unconscionable is that so many projects do not advance the field. Alzheimer’s disease, Traumatic Brain Injury and AIDs research are all examples heavily funded scientific political cesspools that have shown unremarkable progress in the past 20 years.

It is time to turn back the clock when NASA, NIH, DARPA, DoD, ONR and CDC when these organizations were led by people who were public intellectuals and visionaries. It was their mandate to identify the best talent and facilitate conquering an objective. Proficiency in filling out forms was low on the list of priorities. Speed and intellect were what counted. The average age of the team of scientists and engineers that put a man on the moon was 26. The average age of NIH grantee is approaching retirement age. Scientists and engineers make their great leaps forward in their 30’s and 40’s and generally extend the same line of work for the balance of the careers. Of course, there are exceptional minds that are super intellects (1% of 1%) and should be given unique permanent funding to indulge their interests. For the rest of the scientific, engineering and math communities, funding should be limited to 3 to 5 years renewable for 5 years. The funding should be based on clear objectives. Progress should be judged by peers in other fields as well as those in the art. Panels used by funding agencies tend to be filled with people who are third and fourth tier minds in the art who have nothing better to do than sit on a government panel. Identify people that don’t want to serve and who have something better to do and encourage them to identify and support the next generation of big brains.

People in the field, if infected with any degree of humility, can identify the most talented minds and people outside the field can generally identify those that are truly gifted from those that are merely hardworking. This will disturb many in Congress because the balance of funding will be concentrated on the coasts at the leading US research institutions like Columbia, Harvard, Yale, UCal, and Stanford and leave out East Podunk University. On the other hand, some of the most creative thinkers find their homes in the most unlikely places as their radical thoughts run contrary to orthodox views. It is incumbent on the federal government to find skilled administrators to find the talent and support it regardless of location or political influence. It is time to move the ball forward. It is also time to move it quickly and cost-effectively. More money without better methods will get us nowhere.

Part II – will deal with the US federal government’s provision of healthcare.

November is National Alzheimer's Disease Awareness Month

President Ronald Reagan designated November as National Alzheimer’s Disease Awareness Month in 1983. At the time, fewer than 2 million Americans had Alzheimer’s; today, the number of people with the disease has soared to more than 5 million. By 2050, 11 to 16 million people will likely have Alzheimer’s.

Later diagnosed with Alzheimer’s himself, President Reagan died in 2003.

While there is much we don’t yet know about Alzheimer’s disease, tremendous progress has been made since 1983. National Alzheimer’s Disease Awareness month to raise awareness of Alzheimer's disease and to shed light on the importance of finding breakthroughs in diagnosis, prevention, treatments and, eventually, a cure.

The Healing Project would also like to emphasize that Alzheimer's is only one of several types of dementia and there is a grwoing body of evidence that many patients present with multiple forms of dementia. The cure will not be easy and will require an open mind.

National Alzheimer's Disease Awareness Month
Alzheimer's Association
225 North Michigan Avenue, 17th Floor
Chicago, IL 60601-7633
(800) 272-3900
(866) 699-1246
info@alz.org
http://www.alz.org/
Materials available
Contact: None designated

November is American Diabetes Month

The Healing Project cannot understate the magnitude of the diabetes epidemic. This is the most serious health problem impacting the US, if not the world. It is time to get this under control.

All About Diabetes

Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. The cause of diabetes continues to be a mystery, although both genetics and environmental factors such as obesity and lack of exercise appear to play roles.

There are 20.8 million children and adults in the United States, or 7% of the population, who have diabetes. While an estimated 14.6 million have been diagnosed with diabetes, unfortunately, 6.2 million people (or nearly one-third) are unaware that they have the disease.

American Diabetes Month
American Diabetes Association
1701 North Beauregard Street
Alexandria, VA 22311
(800) DIABETES (342-2383)
(703) 549-1500
(703) 549-6995 Fax
askada@diabetes.org
http://www.diabetes.org/
Materials available
Contact: Local Affiliates

For Information About Vision Related Diabetes Problems:
Diabetic Eye Disease Month
Prevent Blindness America
211 West Wacker Drive, Suite 1700
Chicago, IL 60606
(800) 331-2020
(847) 843-8458 Fax
info@preventblindness.org
http://www.preventblindness.org/
Materials available
Contact: PBA Consumer and Patient Hotline

November is Lung Cancer Awareness Month

Lung Cancer research is terribly underfunded even though billions of dollars of taxes are taken every year from smokers. It is time that these funds are directed, as they were intended, to pay for healthcare. The Healing Project advocates a small portion of these funds be allocated to Lung Cancer research and diagnosis. This new funding would represent a leap in an order of magintude and bring this scourge to an end.

Lung Cancer Facts
Lung cancer is the leading cause of cancer death in the United States.
Lung cancer causes 30% of all cancer deaths.
Lung cancer is the leading cancer killer among Caucasians, African-Americans, Asians and Hispanic males.
In 2007, an estimated 213,380 people were diagnosed with lung cancer and 160,390 died from it.

Lung cancer will kill more people this year than:
• breast cancer
• prostate cancer
• colon cancer
• liver cancer
• kidney cancer
• melanoma...combined

The 5-year survival rate for…
• Breast cancer has reached 88%
• Prostate cancer – 99%
• Colon cancer – 63%
• Lung Cancer – 15%!

Lung cancer will kill three times as many men as prostate cancer this year.
Lung cancer will kill nearly twice as many women as breast cancer this year.
Over 50% of new lung cancer cases will be diagnosed at a very late stage—Stage IIIb or IV— and only 5% of them will live for 5 years.
Current smokers represent 35-40% of new lung cancer cases.
Former smokers represent 50% of new lung cancer cases.
People who never smoked represent 10-15% of new lung cancer cases.
The rate of lung cancer among women has risen 60% since 1990.
Lung cancer surpassed breast cancer as the #1 cancer killer of women in 1987.
31,000 more women will die of lung cancer than breast cancer this year.
3 out of 5 patients diagnosed with lung cancer will die within 12 months.
Only 15% of lung cancer patients will be diagnosed early enough to survive for five years or more, compared with 5-year survival rates of 88% for breast cancer, 100% for prostate cancer, and 64% for colon cancer.
Despite lung cancer being the #1 cancer killer, roughly $1,800 is spent per lung cancer death compared to around $23,000 per breast cancer death for research!

Sources:
The Thomas G. Labrecque Foundation
Joan's Legacy
Lung Cancer Alliance

Lung Cancer Awareness Month
Lung Cancer Alliance
1747 Pennsylvania Avenue NW, Suite 1150
Washington, DC 20006
(800) 298-2436 Lung Cancer Information Line
(202) 463-2080
info@lungcanceralliance.org
www.lungcanceralliance.org
Materials available
Contact: Kay Cofrancesco

November is Pancreatic Cancer Awareness Month

Quick Facts About Pancreatic Cancer:

• It is the 4th leading cause of cancer deaths in the U.S.Pancreatic cancer is the 4th leading cause of cancer death in the United States.


• It is the 3rd leading cause of cancer death among 40-59 year old men.


• Approximately 37,170 people will be diagnosed with pancreatic cancer this year in the United States.


• Approximately 33,370 people will die of pancreatic cancer this year in the United States.


• The number of Americans diagnosed each year of pancreatic cancer continues to rise.


• For all stages of pancreatic cancer combined, the five year survival rate is only 5%; the lowest survival rate of all major cancers. The average life expectancy after diagnosis with metastatic disease is just 3-6 months.


• 52% of pancreatic cancer patients are diagnosed with metastatic. Men are 20% more likely to develop cancer of the pancreas than women.


• African Americans are 40-50% more likely to develop cancer of the pancreas than Caucasians.


• Less than2% of the National Cancer Institutes was spent of Pancreatic Cancer Research.

It is time to take action against a disease that has been ignored for too long.

Pancreatic Cancer Awareness Month
Pancreatic Cancer Action Network
2141 Rosecrans Avenue, Suite 7000
El Segundo, CA 90245
(877) 272-6226
(310) 725-0025
(310) 725-0029 Fax
information@pancan.org
http://www.pancan.org/
Materials available
Contact: Sue Kim

October 31st is Interstitial Cystitis Awareness Day

What is Interstitial Cystitis
IC is a painful and often debilitating chronic condition where the bladder lining becomes irritated and inflamed causing symptoms such as pain in the pelvis, bladder, back or thighs; an increased need to urinate frequently or urgently; and/or pain during/after sexual intercourse.

Research indicates that the number of people who have IC may actually be higher than the current estimate of two million Americans since many people are not appropriately diagnosed and continue to face the daily frustrations associated with IC.

Diagnosis
IC can be tricky to diagnose because symptoms are easily mistaken for other urologic and gynecologic disorders, such as endometriosis, recurrent urinary tract infections and overactive bladder. As a result, it can take years and numerous visits to multiple healthcare professionals to achieve a correct diagnosis. In the survey, more than half of the respondents (58 percent) said their IC diagnosis took a year or more. More than half (56 percent) also said they had seen three or more healthcare professionals before their diagnosis.

Some Education Films





Interstitial Cystitis Awareness Day
National Association of Nurse Practitioners in Women's Health
505 C Street NE
Washington, DC 20002
(202) 543-9693
(202) 543-9858 Fax
info@npwh.org
www.npwh.org
Materials available
Contact: Susan Wysocki

October is National Spina Bifida Awareness Month

What Is Spina Bifida?
Spina Bifida, or “split spine,” is a condition that occurs in the embryo within the first month of pregnancy; it results from an incomplete closure of the spinal column. Spina Bifida is the most frequently occurring permanently disabling birth defect. Every day in the US, an average of eight babies are affected by Spina Bifida or a similar birth defect of the brain and spine.

What Causes Spina Bifida?
The cause of Spina Bifida is not known with certainty. However, scientists believe that geneti Many things can affect a baby, including family genes and things women may come in contact with during pregnancy. Taking folic acid cannot guarantee having a healthy baby, but it can help.

Many things can affect a baby, including family genetics and things women may come in contact with during pregnancy. Taking folic acid cannot guarantee having a healthy baby, but it can help reduce the risk of neural tube defects like Spina Bifida.

What is folic acid?
Folic acid is a B-vitamin that helps build healthy cells. During periods of rapid growth, such as pregnancy and fetal development, the body's requirement for this vitamin increases. Research has shown that if all women who could possibly become pregnant were to take a multivitamin with folic acid, the risk of neural tube defects like Spina Bifida could be reduced by up to 70%. Since Spina Bifida occurs early in pregnancy, often before a woman knows she is pregnant, it is important to take folic acid every day. Taking folic acid before and during early pregnancy reduces the risk of Spina Bifida and other neural tube defects.

National Spina Bifida Awareness Month
Spina Bifida Association
4590 MacArthur Boulevard NW, Suite 250
Washington, DC 20007-4226
(800) 621-3141
(202) 944-3285
(202) 944-3295 Fax
sbaa@sbaa.org
www.spinabifidaassociation.org
Materials available
Contact: Amanda Darnley

October is National Celiac Disease Awareness Month

Celiac Sprue Association/ United States of America, Inc. (CSA/USA, Inc) is a member based non-profit organization dedicated to helping individuals with celiac disease and dermatitis herpetiformis worldwide through education, research and support.

National Celiac Disease Awareness Month
Celiac Sprue Association
P.O. Box 31700
Omaha, NE 68131-0700
(877) 272-4272
(402) 643-4108 Fax
celiacs@csaceliacs.org
www.csaceliacs.org
Materials available
Contact: Mary Schluckebier

A Proven Technology Detects mild-Traumatic Brain Injury in Combat

On October 12 at the International Conference on Behavioral Health and Traumatic Brain Injury, St. Joseph's Regional Medical Center, Paterson, NJ, HeadMinder, Inc., presented results of the first Military IRB-approved prospective study to be conducted in-Theater.

The study compared the HeadMinder Cognitive Stability Index (CSI) computerized test battery and the Department of Defense (DoD) Automated Neuropsychological Assessment Metric (ANAM) with the Repeatable Battery for Assessment of Neuropsychological Symptoms (RBANS), a paper-and-pencil neurocognitive test currently used by the DoD to screen soldiers.

The study was designed by Lt. Col. (sep.) Gerald Grant, MD (USAF), Maj. William Isler, PhD (USAF), Maj. Monty Baker, PhD (USAF), David Erlanger, PhD (Chief Scientific Officer and co-Founder of HeadMinder), Tanya Kaushik, PsyD, and Col. Robert Seegmiller (USAF). The objective was to determine the validity and reliability of both computerized screening measures as compared to the RBANS. The CSI was accurate in assessing the severity of cognitive compromise following concussive blast injuries. The CSI Total Score correlated very strongly with the RBANS Total Score (.789) and also showed strong concurrent validity with the RBANS in the domains of Attention (.706) and Memory (.680), domains critical in the assessment of blast-related concussion. ANAM was not useful for identifying memory problems, the domain most frequently impaired on the RBANS, and only a subset of ANAM measures seemed useful for screening attention problems.

The CSI is a 30-minute, Internet-based, computerized test that provides automated, objective measures of attention, memory, response speed, and processing speed for initial evaluation of cognitive functioning. The CSI produces standardized reports that enable triage and decision-making appropriate to a user's qualifications – from medic to neuropsychologist to neurologist and other treatment team members.

Dr. David Erlanger, Chief Scientific Officer of HeadMinder, commented, "The CSI has now been shown, under combat conditions, to be the only telemedicine tool capable of serving the needs of the armed services. Especially given the large backlog of unscreened service members exposed to blasts, the HeadMinder System offers a simple, accurate, and objective screening method that can play a key role in identifying and treating servicemen and servicewomen with undiagnosed brain injuries. The CSI is unique in its ability to track improvement over time as soldiers travel between the Military Health System and the Veterans Administration and civilian medical resources. We believe the HeadMinder platform provides the Department of Defense the opportunity to fully comply with the Wounded Warriors Act by screening and tracking exposed service members' long-term well-being. If implemented today, the entire backlog could be cleared in less than two years."

After 5 years of ducking the issue, the DoD can get off their collective bottoms and start screening the 400,000 troops that have been exposed to blasts in Iraq and Afghanistan. While the study in no way implied that every service member exposed suffered m-TBI, it did imply that approximately 20,000 service members have suffered the injury. It is time to identify them and treat them. There is no need for mindless dead-end research projects.

Since S. Ward Casscells, MD , Undersecretary of Defense - Healthcare, has actively and willfully avoided detecting and treating both m-TBI and mental health issues, it is time to contact your representatives to start getting answers (find your representative, find your senator). His desire to deny disability payments and under report causalities is repellent.

A special note if you are represented by any of the following members:

Senator Patty Murray (D-WA)
Senator Hillary Clinton (D-NY)
Congressman Jack Murtha (D-PA)
Congressman Bill Pascrell (D-NJ)
Congressman Todd Platts (R-PA)

make an effort to contact them as they have taken leading positions to help service members with mild-Traumatic Brain Injury, PTSD and mental health issues.

The study was initially funded by the Henry M. Jackson Foundation. After funding was discontinued, the study was completed with funding provided by PanMedix, Inc., and HeadMinder, Inc.

PanMedix was founded in New York City in 1999. Initially focused on the development and deployment of assessment software, the company has evolved to encompass a full range of pharmaceutical and medical assessment services.

Founded in New York City in 1999, HeadMinder is a technology company that is dedicated to the development of Internet-based neurocognitive assessment tools. HeadMinder tests have been shown to be valid and reliable instruments for evaluating cognitive deficits in a range of injuries and illnesses, including concussion, mild-to-moderate TBI, Multiple Sclerosis, ADHD, Alzheimer's Disease, and chemotherapy-induced cognitive dysfunction in cancer patients.