The LEADe study was 18 months in duration and included 640 patients. The patients presented with mild-to-moderate Alzheimer’s disease (AD), the addition of Lipitor (atorvastatin calcium tablets) 80 mg to Aricept® (donepezil HCl) 10 mg showed no significant differences in cognition or global function (key measures of Alzheimer’s progression) compared to placebo plus Aricept 10 mg. No statistically significant results were demonstrated on secondary end-points that included cognitive, behavioral and functional measures.
A more interesting study would be to investigate the statin families prophylactic efficacy on a broad range of dementias. It is reasonably to hypothesize that statins may have a positive effect on a range of dementia by reducing the stress on the coronary system and/or reducing inflammation.
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